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3h3c

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Revision as of 09:56, 8 July 2009

Image:3h3c.png

Template:STRUCTURE 3h3c

Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog

Template:ABSTRACT PUBMED 19428251

About this Structure

3H3C is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Walker DP, Zawistoski MP, McGlynn MA, Li JC, Kung DW, Bonnette PC, Baumann A, Buckbinder L, Houser JA, Boer J, Mistry A, Han S, Xing L, Guzman-Perez A. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3253-8. Epub 2009 Apr 24. PMID:19428251 doi:10.1016/j.bmcl.2009.04.093

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