190d
From Proteopedia
(New page: 200px<br /><applet load="190d" size="450" color="white" frame="true" align="right" spinBox="true" caption="190d, resolution 1.800Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:190d.gif|left|200px]]<br /><applet load="190d" size=" | + | [[Image:190d.gif|left|200px]]<br /><applet load="190d" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="190d, resolution 1.800Å" /> | caption="190d, resolution 1.800Å" /> | ||
'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''<br /> | '''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of d(C4) solved at 2.3-A resolution reveals a | + | The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested. |
==About this Structure== | ==About this Structure== | ||
| - | 190D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 190D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA]. |
==Reference== | ==Reference== | ||
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[[Category: u-dna]] | [[Category: u-dna]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:39:06 2008'' |
Revision as of 09:39, 21 February 2008
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CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)
Overview
The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
About this Structure
190D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764
Page seeded by OCA on Thu Feb 21 11:39:06 2008
