3fli

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3fli.jpg|left|200px]]
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The entry 3fli is ON HOLD until Dec 18 2010
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{{STRUCTURE_3fli| PDB=3fli | SCENE= }}
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Authors: Foster, P.G., Stout, T.J.
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===Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)===
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Description: Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:17:21 2009''
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==About this Structure==
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3FLI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLI OCA].
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==Reference==
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<ref group="xtra">PMID:19159286</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Foster, P G.]]
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[[Category: Stout, T J.]]
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[[Category: Activator]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Alternative splicing]]
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[[Category: Bar]]
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[[Category: Bile acid receptor]]
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[[Category: Dna-binding]]
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[[Category: Fxr]]
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[[Category: Ligand-binding domain]]
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[[Category: Metal-binding]]
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[[Category: Nr1h4]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Receptor]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcriptional regulator]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:44:43 2009''

Revision as of 07:44, 23 December 2009

Image:3fli.jpg

Template:STRUCTURE 3fli

Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)

About this Structure

3FLI is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Flatt B, Martin R, Wang TL, Mahaney P, Murphy B, Gu XH, Foster P, Li J, Pircher P, Petrowski M, Schulman I, Westin S, Wrobel J, Yan G, Bischoff E, Daige C, Mohan R. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J Med Chem. 2009 Feb 26;52(4):904-7. PMID:19159286 doi:10.1021/jm8014124

Page seeded by OCA on Wed Dec 23 09:44:43 2009

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