3eta

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{{Seed}}
 
[[Image:3eta.png|left|200px]]
[[Image:3eta.png|left|200px]]
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{{STRUCTURE_3eta| PDB=3eta | SCENE= }}
{{STRUCTURE_3eta| PDB=3eta | SCENE= }}
===Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor===
===Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor===
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{{ABSTRACT_PUBMED_19394223}}
{{ABSTRACT_PUBMED_19394223}}
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==Disease==
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==About this Structure==
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Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Leprechaunism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Rabson-Mendenhall syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]]
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[[3eta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETA OCA].
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==About this Structure==
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==See Also==
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3ETA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETA OCA].
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*[[Insulin receptor|Insulin receptor]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19394223</ref><references group="xtra"/>
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<ref group="xtra">PMID:019394223</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Stevens, K.]]
[[Category: Stevens, K.]]
[[Category: Tang, J.]]
[[Category: Tang, J.]]
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[[Category: Alternative splicing]]
 
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Carbohydrate metabolism]]
[[Category: Carbohydrate metabolism]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
 
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 20:51:47 2009''
 

Revision as of 13:30, 6 February 2013

Template:STRUCTURE 3eta

Contents

Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

Template:ABSTRACT PUBMED 19394223

About this Structure

3eta is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Patnaik S, Stevens KL, Gerding R, Deanda F, Shotwell JB, Tang J, Hamajima T, Nakamura H, Leesnitzer MA, Hassell AM, Shewchuck LM, Kumar R, Lei H, Chamberlain SD. Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3136-40. Epub 2009 Jan 6. PMID:19394223 doi:10.1016/j.bmcl.2008.12.110

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