User:Tilman Schirmer/Sandbox 201
From Proteopedia
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<applet load='1w25' scene='User:Tilman_Schirmer/Sandbox_201/Loose_dimer/3' size='250' frame='true' align='left' caption='non-activated (1w25)' /> <applet load='2v0n' scene='User:Tilman_Schirmer/Sandbox_201/Tight_dimer/2' size='250' frame='true' align='center' caption='activated (BeF3- modified; 2v0n)' /> | <applet load='1w25' scene='User:Tilman_Schirmer/Sandbox_201/Loose_dimer/3' size='250' frame='true' align='left' caption='non-activated (1w25)' /> <applet load='2v0n' scene='User:Tilman_Schirmer/Sandbox_201/Tight_dimer/2' size='250' frame='true' align='center' caption='activated (BeF3- modified; 2v0n)' /> | ||
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| - | == Non-activated conformation == | ||
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| - | [[1w25]] | ||
| - | <applet load='1w25' scene='User:Tilman_Schirmer/Sandbox_201/Protomer/2' size='300' frame='true' align='right' caption='1w25' /> | ||
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| - | <scene name='User:Tilman_Schirmer/Sandbox_201/Protomer/2'>Protomer</scene>: <scene name='User:Tilman_Schirmer/Sandbox_201/Rec/1'>Rec domain</scene>, | ||
| - | <scene name='User:Tilman_Schirmer/Sandbox_201/Rec2/1'>Rec' domain</scene>, <scene name='User:Tilman_Schirmer/Sandbox_201/Ggdef/1'>GGDEF domain</scene> | ||
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| - | <scene name='User:Tilman_Schirmer/Sandbox_201/Loose_dimer/2'>Loose dimer</scene> | ||
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| - | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
Revision as of 20:55, 20 June 2009
PleD
Contents |
Intro
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from Caulobacter crescentus is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain,
a Rec-like () adaptor domain,
and a C-terminal domain that confers the catalytic acitvity.
The GGDEF domain is named after the highly conserved (in PleD it is GGEEF) that locates to a β-hairpin.
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The motif is part of the as identified in the structure of PleD in complex with .
Allosteric product binding site
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C-di-GMP
Primary inhibition site (Ip)
Secondary inhibition site (Is)
Primary and secondary inhibition sites
Two conformations
non-activated (1w25)
activated (BeF3- modified; 2v0n)
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Activated conformation
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