User:Tilman Schirmer/Sandbox 200

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Revision as of 12:52, 21 June 2009

Cyclic di-GMP signaling

Contents 1 Intro 2 Diguanylate cyclases 3 PleD 4 C-di-GMP specific phosphodiesterases 5 C-di-GMP receptors

Intro

Diguanylate cyclases

The condensation reaction 2 GTP -> c-di-GMP + 2 PPi is catalyzed by GGDEF domains that typically occur in combination with sensory or regulator domains. The structures of two diguanylate cyclases have been determined, both being response regulators with a response regulator receiver (Rec) and a GGDEF output (effector) domain. Response regulators are activated through phosphorylation of a conserved aspartate by cognate histidine kinases.

PleD

C-di-GMP specific phosphodiesterases

C-di-GMP receptors