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1j3l
From Proteopedia
(New page: 200px<br /><applet load="1j3l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j3l, resolution 2.30Å" /> '''Structure of the RNA...) |
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| - | [[Image:1j3l.gif|left|200px]]<br /><applet load="1j3l" size=" | + | [[Image:1j3l.gif|left|200px]]<br /><applet load="1j3l" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1j3l, resolution 2.30Å" /> | caption="1j3l, resolution 2.30Å" /> | ||
'''Structure of the RNA-processing inhibitor RraA from Thermus thermophilis'''<br /> | '''Structure of the RNA-processing inhibitor RraA from Thermus thermophilis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The menG gene product, thought to catalyze the final methylation in | + | The menG gene product, thought to catalyze the final methylation in vitamin K(2) synthesis, has recently been shown to inhibit RNase E in Eschericha coli. The structure of the protein, since renamed RraA, has been solved to 2.3 A using the multiple-wavelength anomalous diffraction method and selenomethionine-substituted protein from Thermus thermophilus. The six molecules in the asymmetric unit are arranged as two similar trimers which have a degree of interaction, suggesting biological significance. The fold does not support the postulated methylation function. Genomic analysis, specifically a lack of an RNase E homologue in cases where homologues to RraA exist, indicates that the function is still obscure. |
==About this Structure== | ==About this Structure== | ||
| - | 1J3L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with MG and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1J3L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
[[Category: Miyano, M.]] | [[Category: Miyano, M.]] | ||
| - | [[Category: RSGI, RIKEN | + | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] |
| - | [[Category: Rehse, P | + | [[Category: Rehse, P H.]] |
| - | [[Category: Tahirov, T | + | [[Category: Tahirov, T H.]] |
[[Category: CL]] | [[Category: CL]] | ||
[[Category: MG]] | [[Category: MG]] | ||
| Line 24: | Line 24: | ||
[[Category: vitamine k2]] | [[Category: vitamine k2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:18:36 2008'' |
Revision as of 11:18, 21 February 2008
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Structure of the RNA-processing inhibitor RraA from Thermus thermophilis
Overview
The menG gene product, thought to catalyze the final methylation in vitamin K(2) synthesis, has recently been shown to inhibit RNase E in Eschericha coli. The structure of the protein, since renamed RraA, has been solved to 2.3 A using the multiple-wavelength anomalous diffraction method and selenomethionine-substituted protein from Thermus thermophilus. The six molecules in the asymmetric unit are arranged as two similar trimers which have a degree of interaction, suggesting biological significance. The fold does not support the postulated methylation function. Genomic analysis, specifically a lack of an RNase E homologue in cases where homologues to RraA exist, indicates that the function is still obscure.
About this Structure
1J3L is a Single protein structure of sequence from Thermus thermophilus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the RNA-processing inhibitor RraA from Thermus thermophilis., Rehse PH, Kuroishi C, Tahirov TH, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1997-2002. Epub, 2004 Oct 20. PMID:15502308
Page seeded by OCA on Thu Feb 21 13:18:36 2008
