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User:Tilman Schirmer/Sandbox 204
From Proteopedia
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(→Secondary inhibition site (Is)) |
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=== Secondary inhibition site (Is) === | === Secondary inhibition site (Is) === | ||
| - | <scene name='User:Tilman_Schirmer/Sandbox_204/ | + | <scene name='User:Tilman_Schirmer/Sandbox_204/Is/1'>Secondary inhibition site</scene> |
''Is this correct?'' | ''Is this correct?'' | ||
Revision as of 15:38, 1 July 2009
WspR
Contents |
Overview
|
: ,
from Pseudomonas aeruginosa is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain and a C-terminal domain that confers the catalytic acitvity.
Although not modified (e.g. phosphorylated) at the active Asp (Asp70), the Rec domains mediate formation of WspR. Two dimers, in turn, are associated by head-to-head contact to a of approximate 222 (D2) symmetry.
i
Allosteric product binding site
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Primary inhibition site (Ip)
Secondary inhibition site (Is)
Is this correct?
Allosteric binding of the product c-di-GMP
C-di-GMP binding to the inhbition sites cross-links two dimers.
