1jes

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(New page: 200px<br /><applet load="1jes" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jes, resolution 1.5&Aring;" /> '''Crystal Structure of ...)
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[[Image:1jes.gif|left|200px]]<br /><applet load="1jes" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1jes, resolution 1.5&Aring;" />
caption="1jes, resolution 1.5&Aring;" />
'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''<br />
'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''<br />
==Overview==
==Overview==
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Stable and selective DNA base pairing by metal coordination was recently, demonstrated with nucleotides containing complementary, pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.;, Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am., Chem. Soc. 2000, 122, 10714-10715). To understand the structural, consequences of introducing this novel base pair into DNA we have solved, the crystal structure of a duplex containing the metallo-base pair. The, structure shows that the bases pair as designed, but in a Z-DNA, conformation. The structure also provides a structural explanation for the, B- to Z-DNA transition in this duplex. Further solution studies, demonstrate that the metallo-base pair is compatible with Z- or B-DNA, conformations, depending on the duplex sequence.
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Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
==About this Structure==
==About this Structure==
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1JES is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].
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1JES is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CU:'>CU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].
==Reference==
==Reference==
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[[Category: Atwell, S.]]
[[Category: Atwell, S.]]
[[Category: Meggers, E.]]
[[Category: Meggers, E.]]
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[[Category: Schultz, P.G.]]
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[[Category: Schultz, P G.]]
[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
[[Category: CU]]
[[Category: CU]]
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[[Category: z-dna]]
[[Category: z-dna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:32:36 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:21:49 2008''

Revision as of 11:21, 21 February 2008

Image:1jes.gif

1jes, resolution 1.5Å

Drag the structure with the mouse to rotate

Crystal Structure of a Copper-Mediated Base Pair in DNA

Overview

Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.

About this Structure

1JES is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038

Page seeded by OCA on Thu Feb 21 13:21:49 2008

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