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3hkj

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===Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
===Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
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{{ABSTRACT_PUBMED_19586901}}
==Disease==
==Disease==
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==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
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[[Category: Zymogen]]
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Revision as of 05:31, 16 September 2009

Image:3hkj.png

Template:STRUCTURE 3hkj

Contents

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Template:ABSTRACT PUBMED 19586901

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3HKJ is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
  • Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200

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