3hs4

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3hs4.jpg|left|200px]]
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The entry 3hs4 is ON HOLD until Paper Publication
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{{STRUCTURE_3hs4| PDB=3hs4 | SCENE= }}
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Authors: Robbins, A.H., Genis, C., Domsic, J., Sippel, K.H., Agbandje-McKenna, M., McKenna, R.
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===Human carbonic anhydrase II complexed with acetazolamide===
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Description: Human carbonic anhydrase II complexed with acetazolamide
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:45:13 2009''
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{{ABSTRACT_PUBMED_19851004}}
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==Disease==
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Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]
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==About this Structure==
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3HS4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS4 OCA].
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==Reference==
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<ref group="xtra">PMID:19851004</ref><ref group="xtra">PMID:2128470</ref><references group="xtra"/>
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Domsic, J.]]
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[[Category: Genis, C.]]
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[[Category: McKenna, R.]]
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[[Category: Robbins, A H.]]
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[[Category: Sippel, K H.]]
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[[Category: 4-thiadiazole-2-sulfonamide]]
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[[Category: 5-acetamido-1]]
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[[Category: Acetazolamide]]
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[[Category: Acetylation]]
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[[Category: Ca 2]]
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[[Category: Ca ii]]
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[[Category: Carbonic anhydrase 2]]
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[[Category: Carbonic anhydrase ii]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Polymorphism]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 15:09:52 2009''

Revision as of 13:09, 9 December 2009

Template:STRUCTURE 3hs4

Contents

Human carbonic anhydrase II complexed with acetazolamide

Template:ABSTRACT PUBMED 19851004

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

3HS4 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sippel KH, Robbins AH, Domsic J, Genis C, Agbandje-McKenna M, McKenna R. High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt, 10):992-5. Epub 2009 Sep 25. PMID:19851004 doi:10.1107/S1744309109036665
  • Vidgren J, Liljas A, Walker NP. Refined structure of the acetazolamide complex of human carbonic anhydrase II at 1.9 A. Int J Biol Macromol. 1990 Dec;12(6):342-4. PMID:2128470

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