1g6o
From Proteopedia
(New page: 200px<br /><applet load="1g6o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g6o, resolution 2.50Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1g6o.gif|left|200px]]<br /><applet load="1g6o" size=" | + | [[Image:1g6o.gif|left|200px]]<br /><applet load="1g6o" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1g6o, resolution 2.50Å" /> | caption="1g6o, resolution 2.50Å" /> | ||
'''CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP'''<br /> | '''CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The type IV secretion system of Helicobacter pylori consists of 10--15 | + | The type IV secretion system of Helicobacter pylori consists of 10--15 proteins responsible for transport of the transforming protein CagA into target epithelial cells. Secretion of CagA crucially depends on the hexameric ATPase, HP0525, a member of the VirB11-PulE family. We present the crystal structure of a binary complex of HP0525 bound to ADP. Each monomer consists of two domains formed by the N- and C-terminal halves of the sequence. ADP is bound at the interface between the two domains. In the hexamer, the N- and C-terminal domains form two rings, which together form a chamber open on one side and closed on the other. A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release. |
==About this Structure== | ==About this Structure== | ||
| - | 1G6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with ADP and PEG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1G6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Helicobacter pylori]] | [[Category: Helicobacter pylori]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Herr, A | + | [[Category: Herr, A B.]] |
[[Category: Lanka, E.]] | [[Category: Lanka, E.]] | ||
| - | [[Category: MCSG, Midwest | + | [[Category: MCSG, Midwest Center for Structural Genomics.]] |
| - | [[Category: Savvides, S | + | [[Category: Savvides, S N.]] |
[[Category: Waksman, G.]] | [[Category: Waksman, G.]] | ||
| - | [[Category: Yeo, H | + | [[Category: Yeo, H J.]] |
[[Category: ADP]] | [[Category: ADP]] | ||
[[Category: PEG]] | [[Category: PEG]] | ||
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[[Category: type iv secretion system]] | [[Category: type iv secretion system]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:41 2008'' |
Revision as of 10:46, 21 February 2008
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CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP
Overview
The type IV secretion system of Helicobacter pylori consists of 10--15 proteins responsible for transport of the transforming protein CagA into target epithelial cells. Secretion of CagA crucially depends on the hexameric ATPase, HP0525, a member of the VirB11-PulE family. We present the crystal structure of a binary complex of HP0525 bound to ADP. Each monomer consists of two domains formed by the N- and C-terminal halves of the sequence. ADP is bound at the interface between the two domains. In the hexamer, the N- and C-terminal domains form two rings, which together form a chamber open on one side and closed on the other. A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release.
About this Structure
1G6O is a Single protein structure of sequence from Helicobacter pylori with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system., Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G, Mol Cell. 2000 Dec;6(6):1461-72. PMID:11163218
Page seeded by OCA on Thu Feb 21 12:46:41 2008
Categories: Helicobacter pylori | Single protein | Herr, A B. | Lanka, E. | MCSG, Midwest Center for Structural Genomics. | Savvides, S N. | Waksman, G. | Yeo, H J. | ADP | PEG | Atpase | Mcsg | Midwest center for structural genomics | Protein structure initiative | Psi | Structural genomics | Type iv secretion system
