3hkj
From Proteopedia
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[[Image:3hkj.png|left|200px]] | [[Image:3hkj.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_19586901}} | {{ABSTRACT_PUBMED_19586901}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3hkj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKJ OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:31:49 2009'' | ||
Revision as of 20:14, 14 March 2011
Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1
Template:ABSTRACT PUBMED 19586901
About this Structure
3hkj is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
- Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200
Categories: Homo sapiens | Thrombin | Bush-Pelc, L. | Cera, E Di. | Chen, Z. | Gandhi, P S. | Page, M J. | Acute phase | Blood coagulation | Calcium | Cell membrane | Cleavage on pair of basic residue | Disease mutation | Disulfide bond | G-protein coupled receptor | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Kringle | Membrane | Pharmaceutical | Phosphoprotein | Polymorphism | Protease | Receptor | Secreted | Serine protease | Transducer | Transmembrane | Zymogen
