User:Amy Kerzmann/Sandbox 1
From Proteopedia
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| - | == M2 Channel from Influenza A == | + | == Inhibition of the M2 Channel from Influenza A == |
| - | + | Overview of Normal Function: | |
---- | ---- | ||
| + | Influenza A virions bind to host cells via interactions between hemagglutinin and host cell gangliosides (or sialyated proteins), which trigger receptor-mediated endocytosis. As the virion-containing endosomes are acidified during the typical maturation process, hemagglutin undergoes a conformational change that leads to membrane fusion. Simultaneously, the M2 channel is activated by the acidic conditions, permitting the flow of proteins from the endosomal lumen to the inside of the viral envelope. This acidification process enhances the rate of viral uncoating that releases viral RNA and other components into the cytosol of the infected cell. In this manner, the function of the M2 channel is essential for viral infectivity. | ||
| - | The M2 | + | Channel Structure: |
| + | ---- | ||
| + | The M2 proton channel of influenza A is a homotetramer. The central core of this protein is comprised of four transmembrane helices, one from each monomeric subunit. | ||
| - | ''Structural basis for the function and inhibition of an influenza virus proton channel., Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF, Nature. 2008 Jan 31;451(7178):596-9. PMID:[http://www.ncbi.nlm.nih.gov/sites/entrez/18235504 18235504]'' | ||
| - | + | <applet load='2kad' size='300' frame='true' align='right' caption='Insert caption here' /> | |
| + | Channel Function: | ||
| + | ---- | ||
| + | Influenza A virions bind to host cells via interactions between hemagglutinin and gangliosides (or sialyated proteins), which triggers receptor-mediated endocytosis. As the virion-containing endosomes are acidified during their typical maturation process, the M2 channel is activated. | ||
| - | <applet load='3bkd' size='300' frame='true' align='right' caption='Insert caption here' /> | ||
References | References | ||
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Revision as of 04:27, 18 September 2009
Inhibition of the M2 Channel from Influenza A
Overview of Normal Function:
Influenza A virions bind to host cells via interactions between hemagglutinin and host cell gangliosides (or sialyated proteins), which trigger receptor-mediated endocytosis. As the virion-containing endosomes are acidified during the typical maturation process, hemagglutin undergoes a conformational change that leads to membrane fusion. Simultaneously, the M2 channel is activated by the acidic conditions, permitting the flow of proteins from the endosomal lumen to the inside of the viral envelope. This acidification process enhances the rate of viral uncoating that releases viral RNA and other components into the cytosol of the infected cell. In this manner, the function of the M2 channel is essential for viral infectivity.
Channel Structure:
The M2 proton channel of influenza A is a homotetramer. The central core of this protein is comprised of four transmembrane helices, one from each monomeric subunit.
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Channel Function:
Influenza A virions bind to host cells via interactions between hemagglutinin and gangliosides (or sialyated proteins), which triggers receptor-mediated endocytosis. As the virion-containing endosomes are acidified during their typical maturation process, the M2 channel is activated.
References
