Sandbox 43
From Proteopedia
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| - | =='''α-lactalbumin''' == | + | =='''Introduction to α-lactalbumin''' == |
| - | α-lactalbumin is a whey protein that is only found in milk and the mammary gland and is involved in production of lactose. α-lactalbumin is produced in the endoplasmic reticulum. When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis. The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex. Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction: | + | α-lactalbumin is a whey protein that is only found in milk and the mammary gland and is involved in production of lactose. α-lactalbumin is produced in the endoplasmic reticulum. When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.<ref>Neville MC.. 2009. Introduction: alpha-lactalbumin, a multifunctional protein that specifies lactose synthesis in the Golgi. '' J Mammary Gland Biol Neoplasia.'' (3):211-2</ref> The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex. Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction: |
UDP-D-galactose + D-glucose -- lactose + UDP. | UDP-D-galactose + D-glucose -- lactose + UDP. | ||
Revision as of 02:13, 20 September 2009
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Introduction to α-lactalbumin
α-lactalbumin is a whey protein that is only found in milk and the mammary gland and is involved in production of lactose. α-lactalbumin is produced in the endoplasmic reticulum. When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.[1] The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex. Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction:
UDP-D-galactose + D-glucose -- lactose + UDP.
α-lactalbumin is highly similar to the c-type lysozymes sharing primary, secondary and tertiary structures. It is supposed that α-lactalbumin has evoled from c-type lysozyme, however the function of α-lactalbumin is distinct from c-type lysozyme.
Secondary Structure of α-lactalbumin
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| 1a4v, resolution 1.80Å () | |||||||||
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| Ligands: | |||||||||
| Activity: | Lactose synthase, with EC number 2.4.1.22 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
