Sandbox 81
From Proteopedia
| Line 3: | Line 3: | ||
== '''Alpha Lactalbumin''' == | == '''Alpha Lactalbumin''' == | ||
| - | + | ||
α-lactalbumin is a major protein in all kinds of milk studied so far. <ref name="vilotte"> Vilotte JL. Alpha-lactalbumin: Gene Structure and Expression. <http://mammary.nih.gov/Reviews/gene_expression/Vilotte001/index.html>. </ref> | α-lactalbumin is a major protein in all kinds of milk studied so far. <ref name="vilotte"> Vilotte JL. Alpha-lactalbumin: Gene Structure and Expression. <http://mammary.nih.gov/Reviews/gene_expression/Vilotte001/index.html>. </ref> | ||
α- lactalbumin contributes to cell lytic activity, cell growth inhibition, and apoptosis but most importantly, it interacts with UDP-galactosyltransferase <ref name="vilotte"> </ref> to form lactose synthetase via the following reaction: | α- lactalbumin contributes to cell lytic activity, cell growth inhibition, and apoptosis but most importantly, it interacts with UDP-galactosyltransferase <ref name="vilotte"> </ref> to form lactose synthetase via the following reaction: | ||
| Line 13: | Line 13: | ||
== Structure == | == Structure == | ||
| + | α-lactalbumin is a small globular protein which is stabilized by four disulfide bonds with two structural domains. One domain is rich in α-helices, the other is rich in β-sheets and has a calcium binding site. <ref name="energetics"> Hendrix TM, Griko Y, Privalov P. 1996. Energetics of structural domains in α-lactalbumin. Protein Science. 5923-5931.</ref> | ||
<scene name='Sandbox_81/Secondary_structure/1'>Secondary structure</scene>: with alpha helices shown in pink rockets, and beta sheets shown in yellow planks. | <scene name='Sandbox_81/Secondary_structure/1'>Secondary structure</scene>: with alpha helices shown in pink rockets, and beta sheets shown in yellow planks. | ||
Revision as of 03:35, 20 September 2009
Contents |
Alpha Lactalbumin
α-lactalbumin is a major protein in all kinds of milk studied so far. [1] α- lactalbumin contributes to cell lytic activity, cell growth inhibition, and apoptosis but most importantly, it interacts with UDP-galactosyltransferase [1] to form lactose synthetase via the following reaction:
UDP-galactose + glucose -+ lactose + UDP [2]
| |||||||||
| 1a4v, resolution 1.80Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | |||||||||
| Activity: | Lactose synthase, with EC number 2.4.1.22 | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure
α-lactalbumin is a small globular protein which is stabilized by four disulfide bonds with two structural domains. One domain is rich in α-helices, the other is rich in β-sheets and has a calcium binding site. [3]
: with alpha helices shown in pink rockets, and beta sheets shown in yellow planks.
: with nonpolar side chains in gray, polar side chains in purple, and associated water molecules in red.
: calcium ligands with amino acid contacts. water in pink, oxygen in red.
:cations in blue, anions in red, hydrophobic in gray, polar uncharged in light purple, backbone in dark purple.
Function
Recent Studies
References
- ↑ 1.0 1.1 Vilotte JL. Alpha-lactalbumin: Gene Structure and Expression. <http://mammary.nih.gov/Reviews/gene_expression/Vilotte001/index.html>.
- ↑ Fitzgerald DK, Brodbeck URS, Kiyosawa I, Mawal R, Colvin B, Ebner KE. 1970. α-lactalbumin and the Lactose Synthetase Reaction. The Journal of Biological Chemistry. 245(8): 2103-2108.
- ↑ Hendrix TM, Griko Y, Privalov P. 1996. Energetics of structural domains in α-lactalbumin. Protein Science. 5923-5931.
