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3hr1
From Proteopedia
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===Discovery of novel inhibitors of PDE10A=== | ===Discovery of novel inhibitors of PDE10A=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3hr1]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR1 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Phosphodiesterase|Phosphodiesterase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019630403</ref><references group="xtra"/> |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Marr, E S.]] | [[Category: Marr, E S.]] | ||
[[Category: Pandit, J.]] | [[Category: Pandit, J.]] | ||
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Camp]] | [[Category: Camp]] | ||
[[Category: Camp-binding]] | [[Category: Camp-binding]] | ||
[[Category: Cgmp]] | [[Category: Cgmp]] | ||
[[Category: Cgmp-binding]] | [[Category: Cgmp-binding]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| - | [[Category: Hydrolase | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
[[Category: Magnesium]] | [[Category: Magnesium]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Pde10 inhibitor]] | [[Category: Pde10 inhibitor]] | ||
[[Category: Phosphodiesterase 10a]] | [[Category: Phosphodiesterase 10a]] | ||
| - | [[Category: Zinc]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:16:24 2009'' | ||
Revision as of 02:09, 26 July 2012
Contents |
Discovery of novel inhibitors of PDE10A
Template:ABSTRACT PUBMED 19630403
About this Structure
3hr1 is a 1 chain structure of Phosphodiesterase with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
See Also
Reference
- Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). J Med Chem. 2009 Jul 24. PMID:19630403 doi:10.1021/jm900521k
