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1p1y
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(New page: 200px<br /><applet load="1p1y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p1y, resolution 2.10Å" /> '''Crystal structure of...)
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Revision as of 23:42, 24 November 2007
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Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)
Overview
DNA has proved to be a versatile material for the rational design and, assembly of nanometer scale objects. Here we report the crystal structure, of a continuous three-dimensional DNA lattice formed by the self-assembly, of a DNA 13-mer. The structure consists of stacked layers of parallel, helices with adjacent layers linked through parallel-stranded base, pairing. The hexagonal lattice geometry contains solvent channels that, appear large enough to allow 3'-linked guest molecules into the crystal., We have successfully used these parallel base pairs to design and produce, crystals with greatly enlarged solvent channels. This lattice may have, applications as a molecular scaffold for structure determination of guest, molecules, as a molecular sieve, or in the assembly of molecular, electronics. Predictable non-Watson-Crick base pairs, like those described, here, may present a new tool in structural DNA nanotechnology.
About this Structure
1P1Y is a Protein complex structure of sequences from [1] with MG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:15324813
Page seeded by OCA on Sun Nov 25 01:50:06 2007
