1t25

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[[Category: Vivas, L.]]
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[[Category: Winter, V J.]]
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[[Category: Oxidoreductase]]
[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
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Revision as of 11:39, 1 October 2009

Template:STRUCTURE 1t25

Plasmodium falciparum lactate dehydrogenase complexed with NADH and 3-hydroxyisoxazole-4-carboxylic acid

Template:ABSTRACT PUBMED 15117937

About this Structure

1T25 is a 1 chain structure of sequence from Plasmodium falciparum. The June 2008 RCSB PDB Molecule of the Month feature on Lactate Dehydrogenase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_6. Full crystallographic information is available from OCA.

Reference

  • Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, Garcia-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarro R, Mallo A, Gomez de las Heras F. Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem. 2004 Jul 23;279(30):31429-39. Epub 2004 Apr 26. PMID:15117937 doi:10.1074/jbc.M402433200

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