User:Anat Levit/Sandbox 1
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(New page: Prokineticin 1 (PK1) and its close homologue PK2 are two secreted proteins, which belong to the AVIT protein family. They are small related peptides of 80-90 amino acids in length, sharing...)
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Revision as of 12:36, 6 October 2009
Prokineticin 1 (PK1) and its close homologue PK2 are two secreted proteins, which belong to the AVIT protein family. They are small related peptides of 80-90 amino acids in length, sharing 10 conserved cysteins, which create a five disulphide-bridged motif (colipase fold) and an identical amino-termini – AVIT. PK's are expressed in a wide array of peripheral tissues, including the steroidogenic glands (such as the ovary, testis and adrenal gland), but also in the gastrointestinal tract, nervous system, bladder, bone marrow and prostate. PKs exert their biological function through activation of two homologous G-protein coupled receptors (see Wikipedia: G protein-coupled receptor), termed Prokineticin receptor 1 (PROKR1) and Prokineticin receptor 2 (PROKR2). These receptors share 85% sequence homology, which is a high value among known GPCRs. The proteins diverse mainly in their extra and intra-cellular tails.
