2zvt

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'''Unreleased structure'''
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{{Seed}}
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[[Image:2zvt.jpg|left|200px]]
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The entry 2zvt is ON HOLD until Paper Publication
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{{STRUCTURE_2zvt| PDB=2zvt | SCENE= }}
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Authors: Waku, T., Oyama, T., Shiraki, T., Morikawa, K.
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===Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2===
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Description: Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:34:09 2008''
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(as it appears on PubMed at http://www.pubmed.gov), where 19101554 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19101554}}
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==Disease==
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Known disease associated with this structure: Carotid intimal medial thickness 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Insulin resistance, severe, digenic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Lipodystrophy, familial partial, type 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Obesity, severe OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Obesity, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Diabetes, type 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]], Glioblastoma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601487 601487]]
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==About this Structure==
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2ZVT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVT OCA].
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==Reference==
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<ref group="xtra">PMID:19101554</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Morikawa, K.]]
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[[Category: Oyama, T.]]
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[[Category: Shiraki, T.]]
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[[Category: Waku, T.]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Anti parallel helix sandwich]]
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[[Category: Diabetes mellitus]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Obesity]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 13:53:39 2009''

Revision as of 11:53, 7 October 2009

Image:2zvt.jpg

Template:STRUCTURE 2zvt

Contents

Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2

Template:ABSTRACT PUBMED 19101554

Disease

Known disease associated with this structure: Carotid intimal medial thickness 1 OMIM:[601487], Insulin resistance, severe, digenic OMIM:[601487], Lipodystrophy, familial partial, type 3 OMIM:[601487], Obesity, severe OMIM:[601487], Obesity, resistance to OMIM:[601487], Diabetes, type 2 OMIM:[601487], Glioblastoma, susceptibility to OMIM:[601487]

About this Structure

2ZVT is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Waku T, Shiraki T, Oyama T, Morikawa K. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. FEBS Lett. 2009 Jan 22;583(2):320-4. Epub 2008 Dec 26. PMID:19101554 doi:10.1016/j.febslet.2008.12.017

Page seeded by OCA on Wed Oct 7 13:53:39 2009

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