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1te4

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Revision as of 23:56, 24 November 2007

Image:1te4.jpg

1te4

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Solution structure of MTH187. Ontario Centre for Structural Proteomics target MTH0187_1_111; Northeast Structural Genomics Target TT740

Overview

With the completion of genome sequencing projects, there are a large, number of proteins for which we have little or no functional information., Since protein function is closely related to three-dimensional, conformation, structural proteomics is one avenue where the role of, proteins with unknown function can be investigated. In the present, structural project, the structure of MTH187 has been determined by, solution-state NMR spectroscopy. This protein of 12.4 kDa is one of the, 424 non-membrane proteins that were cloned and purified for the structural, proteomic project of Methanobacterium thermoautotrophicum [Christendat, D., Yee, A., Dharamsi, A., Kluger, Y., Gerstein, M., Arrowsmith, C.H. and, Edwards, A.M. (2000) Prog. Biophys. Mol. Biol., 73, 339-345]., Methanobacterium thermoautotrophicum is a thermophilic archaeon that grows, optimally at 65 degrees C. A particular characteristic of this, microorganism is its ability to generate methane from carbon dioxide and, hydrogen [Smith, D.R., Doucette-Stamm, L.A., Deloughery, C., Lee, H., Dubois, J., Aldredge, T., Bashirzadeh, R., Blakely, D., Cook, R., Gilbert, K., Harrison, D., Hoang, L., Keagle, P., Lumm, W., Pothier, B., Qiu, D., Spadafora, R., Vicaire, R., Wang, Y., Wierzbowski, J., Gibson, R., Jiwani, N., Caruso, A., Bush, D., Reeve, J. N. et al. (1997) J. Bacteriol., 179, 7135-7155].

About this Structure

1TE4 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats., Julien O, Gignac I, Hutton A, Yee A, Arrowsmith CH, Gagne SM, J Biomol NMR. 2006 Jun;35(2):149-54. Epub 2006 May 31. PMID:16819590

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