Ribosome
From Proteopedia
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==Structure== | ==Structure== | ||
| + | The particular structures for which the prize was awarded were published in 2000 and were subsequently refined or improved upon: | ||
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| + | Yonath lab structures: [1fka], improved in [1i94] [1i95] [1i96] [1i97] | ||
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| + | Ramakrishnan lab structures: [1fjf] which was later refine to [1j5e] | ||
| + | [1fjg] | ||
| + | |||
| + | Steitz and Moore lab structures: [1ffk] and and later refined to give [1jj2] and then refined to give [1s72] | ||
Revision as of 19:42, 8 October 2009
The Ribosome
The protein synthesis machine of cells.
Background
Venkatraman Ramakrishnan of the M.R.C. Laboratory of Molecular Biology in Cambridge, England; Thomas A. Steitz of Yale University; and Ada E. Yonath of the Weizmann Institute of Science in Rehovot, Israel the 2009 Nobel Prize in Chemistry for their for their work revealing the atomic details of the molecular machine that make proteins in all cells, the ribosome. Others made significant contributions to the detailed structure of this machine, as poignantly summarized by Jeremy Berg, current Director of National Institute of General Medical Sciences, in his announcement, "The Nobel committee has the daunting challenge of limiting itself to up to three laureates for each prize. Several other long-time NIGMS grantees who also contributed greatly to our understanding of the structure and function of the ribosome include Peter Moore, Harry Noller and Joachim Frank." The American Society for Biochemistry and Molecular Biology posted an announcement of the prize echoing this sentiment as well.
The ribosome is a large complex composed of RNA and protein. The size of the ribosomes and the two subunits that come together in active translation made for a daunting task in structure determination. Beyond providing us immense insight into the general molecular details of protein synthesis in every organism, the impact of these structures will be far-reaching as new generations of antibiotics likely to rely in this ground-breaking work.
Structure
The particular structures for which the prize was awarded were published in 2000 and were subsequently refined or improved upon:
Yonath lab structures: [1fka], improved in [1i94] [1i95] [1i96] [1i97]
Ramakrishnan lab structures: [1fjf] which was later refine to [1j5e] [1fjg]
Steitz and Moore lab structures: [1ffk] and and later refined to give [1jj2] and then refined to give [1s72]
Proteopedia Page Contributors and Editors (what is this?)
Wayne Decatur, Michal Harel, Jaime Prilusky, Eric Martz, Alexander Berchansky, Joel L. Sussman, Eran Hodis, David Canner, Margaret Franzen
