1ti8

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(New page: 200px<br /><applet load="1ti8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ti8, resolution 3.00&Aring;" /> '''H7 Haemagglutinin'''...)
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Revision as of 00:06, 25 November 2007

Image:1ti8.gif

1ti8, resolution 3.00Å

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H7 Haemagglutinin

Overview

Comparing the structures of H3, H5 and H9 subtype haemagglutinins, we, deduced a structural basis for including all 15 influenza subtypes in four, clades. H3, H5 and H9 represent three of these clades; we now report the, structure of an H7 HA as a representative of the fourth clade. We confirm, the structure of the turn at the N-terminus of the conserved central, alpha-helix of HA2, and the combination of ionisable residues near the, "fusion peptide" as clade-specific features. We compare the structures of, three H1 HAs with H5 HA in the same clade, to refine our previous, classification and we confirm the division of the clades into two groups, of two. We also show the roles of carbohydrate side chains in the, esterase-fusion domain boundaries in the formation of clade-specific, structural markers.

About this Structure

1TI8 is a Protein complex structure of sequences from Influenza a virus with NAG, NDG and MAN as ligands. Full crystallographic information is available from OCA.

Reference

H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes., Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ, Virology. 2004 Aug 1;325(2):287-96. PMID:15246268

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