3k45
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Revision as of 08:20, 14 October 2009
Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase
Template:ABSTRACT PUBMED 19748785
About this Structure
3K45 is a 1 chain structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. Epub 2009 Aug 22. PMID:19748785 doi:10.1016/j.bmc.2009.08.044
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