3ig6

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3ig6.jpg|left|200px]]
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The entry 3ig6 is ON HOLD until Paper Publication
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{{STRUCTURE_3ig6| PDB=3ig6 | SCENE= }}
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Authors: Adler, M., Whitlow, M.
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===Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex===
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Description: Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 13:42:28 2009''
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{{ABSTRACT_PUBMED_19703768}}
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==Disease==
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Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
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==About this Structure==
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3IG6 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IG6 OCA].
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==Reference==
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<ref group="xtra">PMID:19703768</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: U-plasminogen activator]]
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[[Category: Adler, M.]]
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[[Category: Whitlow, M.]]
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[[Category: Blood coagulation]]
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[[Category: Disulfide bond]]
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[[Category: Egf-like domain]]
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[[Category: Fibrinolysis]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Pharmaceutical]]
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[[Category: Phosphoprotein]]
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[[Category: Plasminogen activation]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: S1 site inhibitor]]
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[[Category: Secreted]]
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[[Category: Selective]]
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[[Category: Serine protease]]
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[[Category: Structure-based drug design]]
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[[Category: Urokinase]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:23:34 2009''

Revision as of 08:23, 14 October 2009

Image:3ig6.jpg

Template:STRUCTURE 3ig6

Contents

Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex

Template:ABSTRACT PUBMED 19703768

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

3IG6 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • West CW, Adler M, Arnaiz D, Chen D, Chu K, Gualtieri G, Ho E, Huwe C, Light D, Phillips G, Pulk R, Sukovich D, Whitlow M, Yuan S, Bryant J. Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5712-5. Epub 2009 Aug 7. PMID:19703768 doi:10.1016/j.bmcl.2009.08.008

Page seeded by OCA on Wed Oct 14 10:23:34 2009

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