1pbr

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Revision as of 00:11, 25 November 2007

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STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE

Overview

Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause, misreading of the genetic code and inhibit translocation. The, aminoglycoside antibiotic paromomycin binds specifically to an RNA, oligonucleotide that contains the 30S subunit A site, and the solution, structure of the RNA-paromomycin complex was determined by nuclear, magnetic resonance spectroscopy. The antibiotic binds in the major groove, of the model A-site RNA within a pocket created by an A-A base pair and a, single bulged adenine. Specific interactions occur between aminoglycoside, chemical groups important for antibiotic activity and conserved, nucleotides in the RNA. The structure explains binding of diverse, aminoglycosides to the ribosome, their specific activity against, prokaryotic organisms, and various resistance mechanisms, and provides, insight into ribosome function.

About this Structure

1PBR is a Protein complex structure of sequences from [1] with PA1, IDG, PA2 and PA3 as ligands. Full crystallographic information is available from OCA.

Reference

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:8910275

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