1l1v

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Revision as of 00:13, 25 November 2007

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UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE

Overview

Many anticancer drugs interact directly with DNA to exert their biological, functions. To date, all noncovalent, intercalating drugs interact with DNA, exclusively by inserting their chromophores into base steps to form, elongated and unwound duplex structures without disrupting the flanking, base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as, examples, we have found a rather unusual interaction mode for the, intercalated drug; the central Watson-Crick X/Y base pairs are looped out, and displaced by the ActD chromophore. The looped-out bases are not, disordered but interact perpendicularly with the base/chromophore and form, specific H bonds with DNA. Such a complex structure provides intriguing, insights into how ligand interacts with DNA and enlarges the repertoires, for sequence-specific DNA recognition.

About this Structure

1L1V is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding., Chou SH, Chin KH, Chen FM, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6625-30. PMID:12011426

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