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3hhm
From Proteopedia
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===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin=== | ===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin=== | ||
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==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA]. | 3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:19805105</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | [[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | ||
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[[Category: Wortmannin]] | [[Category: Wortmannin]] | ||
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Revision as of 07:50, 21 October 2009
Contents |
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
Template:ABSTRACT PUBMED 19805105
Disease
Known disease associated with this structure: Breast cancer, somatic OMIM:[171834], Colorectal cancer, somatic OMIM:[171834], Gastric cancer, somatic OMIM:[171834], Hepatocellular carcinoma, somatic OMIM:[171834], Keratosis, seborrheic, somatic OMIM:[171834], Nevus, epidermal OMIM:[171834], Nonsmall cell lung cancer, somatic OMIM:[171834], Ovarian cancer, somatic OMIM:[171834]
About this Structure
3HHM is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105
Page seeded by OCA on Wed Oct 21 09:50:12 2009
Categories: Homo sapiens | Phosphatidylinositol-4,5-bisphosphate 3-kinase | Amzel, L M. | Gabelli, S B. | Mandelker, D. | Vogelstein, B. | 5-triphosphate | Atp-binding | Disease mutation | H1047r | Kinase | Nucleotide-binding | Oncogene | P110 | P85 | Phosphatidilynositol 3 | Pi3k | Pi3kca | Pik3r1 | Polymorphism | Transferase | Transferase/oncoprotein complex | Wortmannin
