We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1he9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1he9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1he9, resolution 2.40&Aring;" /> '''CRYSTAL STRUCTURE OF...)
Next diff →

Revision as of 00:21, 25 November 2007

Image:1he9.gif

1he9, resolution 2.40Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN

Overview

Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great, medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual, function protein with a C-terminal Ras-ADP-ribosylation domain and an, N-terminal GTPase activating protein (GAP) domain specific for Rho-family, proteins. We report here the three-dimensional structure of the N-terminal, domain of ExoS determined by X-ray crystallography to 2.4 A resolution., Its fold is all helical with a four helix bundle core capped by additional, irregular helices. Loops that are known to interact with Rho-family, proteins show very large mobility. Considering the importance of ExoS in, Pseudomonas pathogenicity, this structure could be of interest for drug, targeting.

About this Structure

1HE9 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structure of the ExoS GTPase activating domain., Wurtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E, FEBS Lett. 2001 Feb 23;491(1-2):26-9. PMID:11226412

Page seeded by OCA on Sun Nov 25 02:29:25 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1he9"
Personal tools