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1d76
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(New page: 200px<br /><applet load="1d76" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d76, resolution 1.300Å" /> '''CRYSTAL AND MOLECUL...)
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Revision as of 00:31, 25 November 2007
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CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS
Overview
The crystal and molecular structure of d(CGUA'CG)2 (where A' is, 2-aminoadenine) has been determined and refined to an R factor of 13.8%, for data 8.0-1.3 A. The structure is very similar to the original Z-DNA, structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., & Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs, in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to, explain the ZI-ZII conformational pattern found in many Z-DNA structures.
About this Structure
1D76 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:1390739
Page seeded by OCA on Sun Nov 25 02:38:43 2007
