1avg
From Proteopedia
(New page: 200px<br /> <applet load="1avg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1avg, resolution 2.60Å" /> '''THROMBIN INHIBITOR ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AVG is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] and [[http://en.wikipedia.org/wiki/Triatoma_pallidipennis Triatoma pallidipennis]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AVG OCA]]. | + | 1AVG is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] and [[http://en.wikipedia.org/wiki/Triatoma_pallidipennis Triatoma pallidipennis]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: ATE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AVG OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: thrombin inhibitor]] | [[Category: thrombin inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:43:45 2007'' |
Revision as of 06:39, 30 October 2007
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THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS
Overview
Triabin, a 142-residue protein from the saliva of the blood-sucking, triatomine bug Triatoma pallidipennis, is a potent and selective thrombin, inhibitor. Its stoichiometric complex with bovine alpha-thrombin was, crystallized, and its crystal structure was solved by Patterson search, methods and refined at 2.6-A resolution to an R value of 0.184. The, analysis revealed that triabin is a compact one-domain molecule, essentially consisting of an eight-stranded beta-barrel. The eight strands, A to H are arranged in the order A-C-B-D-E-F-G-H, with the first four, strands exhibiting a hitherto unobserved up-up-down-down topology. Except, for the B-C inversion, the triabin fold exhibits the regular up-and-down, topology of lipocalins. In contrast to the typical ligand-binding, lipocalins, ... [(full description)]
About this Structure
1AVG is a [Protein complex] structure of sequences from [Bos taurus] and [Triatoma pallidipennis]. Active as [Hydrolase], with EC number [3.4.21.5]. Structure known Active Site: ATE. Full crystallographic information is available from [OCA].
Reference
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug., Fuentes-Prior P, Noeske-Jungblut C, Donner P, Schleuning WD, Huber R, Bode W, Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11845-50. PMID:9342325
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