Chad Sorenson sandbox 1

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	{{STRUCTURE_1gux| PDB=1gux | SCENE= }}		{{STRUCTURE_1gux| PDB=1gux | SCENE= }}
-	'''RETINOBLASTOMA PROTEIN'''	+
		+	== '''RETINOBLASTOMA PROTEIN''' ==
		+
	BACKGROUND		BACKGROUND

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Revision as of 01:37, 29 October 2009

spinqualitylabelsall models PDB ID 1gux Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1gux, resolution 1.85Å ()
Structural annotation: Resources: CATH : 1Guxa00, 1Guxb00 InterPro : Ipr015030, Ipr011028, Ipr013763, Ipr015652, Ipr006670, Ipr002720, Ipr002719 Pfam : PF01858, PF08934, PF01857 SCOP : d1guxa_, d1guxb_ UniProt : P06400
Functional annotation: Cellular component: nucleus PML body chromatin Biological process: regulation of lipid kinase activity negative regulation of cell growth regulation of transcription, DNA-dependent cell cycle checkpoint cell cycle positive regulation of transcription, DNA-dependent negative regulation of transcription from RNA polymerase II promoter transcription chromatin modification negative regulation of protein kinase activity negative regulation of cell cycle M phase androgen receptor signaling pathway G1 phase Molecular function: protein binding transcription coactivator activity DNA binding transcription factor activity kinase binding androgen receptor binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 RETINOBLASTOMA PROTEIN 1.1 RB POCKET BOUND TO E7 LXCXE MOTIF 2 About this Structure 3 Reference

RETINOBLASTOMA PROTEIN

BACKGROUND

Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA.

RB POCKET BOUND TO E7 LXCXE MOTIF

Template:ABSTRACT PUBMED 9495340

About this Structure

1GUX is a 3 chains structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.

Reference

• Lee JO, Russo AA, Pavletich NP. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340 doi:10.1038/36038

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