Michael Purol Sandbox 1

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<scene name='Michael_Purol_Sandbox_1/Cdk6-p19ink4d_inhibitor_compl/1'>CDK6-p19INK4d inhibitor complex</scene>
<scene name='Michael_Purol_Sandbox_1/Cdk6-p19ink4d_inhibitor_compl/1'>CDK6-p19INK4d inhibitor complex</scene>
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==References==
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[1] Barrick D. (2009). Biological Regulation via Ankyrin Repeat Folding. Acs Chemical Biology 4,19-22.
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[2] Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET. (2005). Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24,4065-4080.
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[3] Low C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009). Conformational Switch upon Phosphorylation: Human CDK Inhibitor p19(INK4d) between the Native and Partially Folded State. Acs Chemical Biology 4,53-63.
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[4] Thullberg M, Bartek J, Lukas J. (2000). Ubiquitin/proteasome-mediated degradation of p19(INK4d) determines its periodic expression during the cell cycle. Oncogene 19,2870-2876.

Revision as of 12:55, 3 November 2009

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CDK Inhibitor p19INK4d


PDB ID 1bd8

Drag the structure with the mouse to rotate
1bd8, resolution 1.80Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



p19 in the Cell Cycle

CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase.



References

[1] Barrick D. (2009). Biological Regulation via Ankyrin Repeat Folding. Acs Chemical Biology 4,19-22.

[2] Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET. (2005). Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24,4065-4080.

[3] Low C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009). Conformational Switch upon Phosphorylation: Human CDK Inhibitor p19(INK4d) between the Native and Partially Folded State. Acs Chemical Biology 4,53-63.

[4] Thullberg M, Bartek J, Lukas J. (2000). Ubiquitin/proteasome-mediated degradation of p19(INK4d) determines its periodic expression during the cell cycle. Oncogene 19,2870-2876.

Proteopedia Page Contributors and Editors (what is this?)

Michael Purol, David Canner, Ann Taylor

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