1dc0
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(New page: 200px<br /><applet load="1dc0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dc0, resolution 1.3Å" /> '''CRYSTAL STRUCTURE OF ...)
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Revision as of 00:49, 25 November 2007
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CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG
Overview
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A, has a conformation intermediate between A and B DNA. This trapping of a, stable intermediate suggests that the A and B DNA families are not, discrete, as previously believed. The structure supports a base-centered, rather than a backbone-centered mechanism for the A <--> B transition, mediated by guanine tracts. Interconversion between A and B DNA provides, another means for regulating protein-DNA recognition.
About this Structure
1DC0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897
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