1tz6

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spinqualitylabelsall models 1tz6, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of aminoimidazole riboside kinase from Salmonella enterica complexed with aminoimidazole riboside and ATP analog

Overview

The crystal structures of a Salmonella enterica aminoimidazole riboside, (AIRs) kinase, its complex with the substrate AIRs, and its complex with, AIRs and an ATP analog were determined at 2.6 angstroms, 2.9 angstroms, and 2.7 angstroms, respectively. The product of the Salmonella-specific, gene stm4066, AIRs kinase, is a homodimer with one active site per, monomer. The core structure, consisting of an eight-stranded beta sheet, flanked by eight alpha helices, indicates that AIRs kinase is a member of, the ribokinase superfamily. Unlike ribokinase and adenosine kinase in this, superfamily, AIRs kinase does not show significant conformational changes, upon substrate binding. The active site is covered by a lid formed by, residues 16-28 and 86-100. A comparison of the structure of AIRs kinase, with other ribokinase superfamily members suggests that the active site, lid and conformational changes that occur upon substrate binding may be, advanced features in the evolution of the ribokinase superfamily.

About this Structure

1TZ6 is a Single protein structure of sequence from Salmonella typhimurium lt2 with MG, K, ACP and AIS as ligands. Active as Fructokinase, with EC number 2.7.1.4 Full crystallographic information is available from OCA.

Reference

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:15458630

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