2bgl
From Proteopedia
(New page: 200px<br /> <applet load="2bgl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bgl, resolution 2.8Å" /> '''X-RAY STRUCTURE OF B...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BGL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Podophyllum_peltatum Podophyllum peltatum]] with NAJ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGL OCA]]. | + | 2BGL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Podophyllum_peltatum Podophyllum peltatum]] with NAJ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGL OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:45:11 2007'' |
Revision as of 06:40, 30 October 2007
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X-RAY STRUCTURE OF BINARY-SECOISOLARICIRESINOL DEHYDROGENASE
Overview
(-)-Matairesinol is a central biosynthetic intermediate to numerous, 8-8'-lignans, including the antiviral agent podophyllotoxin in Podophyllum, species and its semi-synthetic anticancer derivatives teniposide, etoposide, and Etopophos. It is formed by action of an enantiospecific, secoisolariciresinol dehydrogenase, an NAD(H)-dependent oxidoreductase, that catalyzes the conversion of (-)-secoisolariciresinol. Matairesinol is, also a plant-derived precursor of the cancer-preventative "mammalian", lignan or "phytoestrogen" enterolactone, formed in the gut following, ingestion of high fiber dietary foodstuffs, for example. Additionally, secoisolariciresinol dehydrogenase is involved in pathways to important, plant defense molecules, such as plicatic acid in the western red cedar, (Thuja ... [(full description)]
About this Structure
2BGL is a [Single protein] structure of sequence from [Podophyllum peltatum] with NAJ as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans., Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C, J Biol Chem. 2005 Apr 1;280(13):12917-26. Epub 2005 Jan 13. PMID:15653677
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