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1u11

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(New page: 200px<br /><applet load="1u11" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u11, resolution 1.55&Aring;" /> '''PurE (N5-carboxyamin...)
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Revision as of 01:00, 25 November 2007

Image:1u11.gif

1u11, resolution 1.55Å

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PurE (N5-carboxyaminoimidazole Ribonucleotide Mutase) from the acidophile Acetobacter aceti

Overview

The crystal structure of Acetobacter aceti PurE was determined to a, resolution of 1.55 A and is compared with the known structures of the, class I PurEs from a mesophile, Escherichia coli, and a thermophile, Thermotoga maritima. Analyses of the general factors that increase protein, stability are examined as potential explanations for the acid stability of, A. aceti PurE. Increased inter-subunit hydrogen bonding and an increased, number of arginine-containing salt bridges appear to account for the bulk, of the increased acid stability. A chain of histidines linking two active, sites is discussed in the context of the proton transfers catalyzed by the, enzyme.

About this Structure

1U11 is a Protein complex structure of sequences from Acetobacter aceti with CIT as ligand. Full crystallographic information is available from OCA.

Reference

Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)., Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004, Sep 23. PMID:15388921

Page seeded by OCA on Sun Nov 25 03:07:35 2007

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