2bgd
From Proteopedia
(New page: 200px<br /> <applet load="2bgd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bgd, resolution 2.40Å" /> '''STRUCTURE-BASED DES...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BGD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, PO4, NA and T1D as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA]]. | + | 2BGD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, PO4, NA and T1D as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:45:15 2007'' |
Revision as of 06:40, 30 October 2007
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Overview
Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
About this Structure
2BGD is a [Single protein] structure of sequence from [Homo sapiens] with CL, PO4, NA and T1D as [ligands]. Active as [Hydrolase], with EC number [3.1.3.48]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Tue Oct 30 08:45:15 2007
Categories: Homo sapiens | Single protein | Black, E. | Breed, J. | Breeze, A.L. | Embrey, K. | Garcia, R. | Gero, T.W. | Godfrey, L. | Kenny, P.W. | Minshull, C.A. | Morley, A.D. | Pannifer, A.D. | Read, J. | Rees, A. | Russell, D.J. | Toader, D. | Tucker, J. | CL | NA | PO4 | T1D | 1 | 1-dioxide template | 2 | 5-thiadiazolidin-3-one-1 | Hydrolase | Protein tyrosine phosphatase
