3iok

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3iok.jpg|left|200px]]
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The entry 3iok is ON HOLD until Paper Publication
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{{STRUCTURE_3iok| PDB=3iok | SCENE= }}
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Authors: Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
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===2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2===
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Description: 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:43:51 2009''
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{{ABSTRACT_PUBMED_19857967}}
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==Disease==
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Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]]
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==About this Structure==
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3IOK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOK OCA].
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==Reference==
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<ref group="xtra">PMID:19857967</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Ledeboer, M W.]]
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[[Category: Pierce, A C.]]
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[[Category: Zuccola, H J.]]
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[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Disease mutation]]
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[[Category: Inhibitor]]
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[[Category: Jak2]]
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[[Category: Janus kinase]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Sh2 domain]]
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[[Category: Transferase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:30:33 2009''

Revision as of 20:30, 11 November 2009

Image:3iok.jpg

Template:STRUCTURE 3iok

Contents

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Template:ABSTRACT PUBMED 19857967

Disease

Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]

About this Structure

3IOK is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ledeboer MW, Pierce AC, Duffy JP, Gao H, Messersmith D, Salituro FG, Nanthakumar S, Come J, Zuccola HJ, Swenson L, Shlyakter D, Mahajan S, Hoock T, Fan B, Tsai WJ, Kolaczkowski E, Carrier S, Hogan JK, Zessis R, Pazhanisamy S, Bennani YL. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6529-33. Epub 2009 Oct 24. PMID:19857967 doi:10.1016/j.bmcl.2009.10.053

Page seeded by OCA on Wed Nov 11 22:30:33 2009

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