3hxo

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3hxo.jpg|left|200px]]
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The entry 3hxo is ON HOLD until Paper Publication
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{{STRUCTURE_3hxo| PDB=3hxo | SCENE= }}
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Authors: Huang, R.H., Sadler, J.E., Fremont, D.H., Diener, J.L., Schaub, R.G.
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===Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding===
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Description: Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:58:17 2009''
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==About this Structure==
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3HXO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXO OCA].
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==Reference==
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<ref group="xtra">PMID:18025536</ref><ref group="xtra">PMID:19422452</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Diener, J L.]]
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[[Category: Fremont, D H.]]
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[[Category: Huang, R H.]]
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[[Category: Sadler, J E.]]
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[[Category: Schaub, R G.]]
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[[Category: Aptamer]]
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[[Category: Arc1772]]
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[[Category: Arc1779]]
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[[Category: Blood clotting/blood clotting regulator complex]]
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[[Category: Blood coagulation]]
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[[Category: Cell adhesion]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hemostasis]]
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[[Category: Isopeptide bond]]
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[[Category: Platelet glycoprotein ib]]
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[[Category: Polymorphism]]
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[[Category: Secreted]]
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[[Category: Ubl conjugation]]
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[[Category: Von willebrand disease]]
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[[Category: Vwf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:08:18 2009''

Revision as of 18:08, 18 November 2009

Image:3hxo.jpg

Template:STRUCTURE 3hxo

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding

About this Structure

3HXO is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007 Dec 4;116(23):2678-86. Epub 2007 Nov 19. PMID:18025536 doi:10.1161/CIRCULATIONAHA.107.724864
  • Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul;7(7):1155-62. Epub 2009 Apr 24. PMID:19422452 doi:10.1111/j.1538-7836.2009.03459.x

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