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1q74

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(New page: 200px<br /><applet load="1q74" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q74, resolution 1.70&Aring;" /> '''The Crystal Structur...)
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Revision as of 01:32, 25 November 2007

Image:1q74.gif

1q74, resolution 1.70Å

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The Crystal Structure of 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)

Overview

The C2-symmetric vinyl sulfoxide, trans-2-methylene-1,3-dithiolane, 1,3-dioxide, was found to react with a range of 3-oxidopyridinium betaines, (bearing different substituents on nitrogen) in high yield and with total, diastereoselectivity. A 2.3:1 mixture of regioisomers was formed with all, of the 3-oxidopyridinium betaines but the ratio was found to change over, prolonged periods of time due to reversibility of the minor regioisomer., 3-Oxidopyridinium betaines bearing methyl substituents at either the 2- or, 6-position were also tested in the cycloaddition process. Improved, regioselectivity (8:1) and again high diastereoselectivity were observed, with the betaine having an additional substituent at the 2-position, but, with betaines having a substituent in the 6-position although high, regioselectivity was observed (9.9:1), the major isomer was formed with, low diastereoselectivity (5.5:4.4). The origin of the regio- and, diastereo-selectivity with all the betaines is discussed. Finally, the, C2-symmetric vinyl sulfoxide, trans-2-methylene-1,3-dithiolane 1,3-dioxide, was reacted with an oxidopyrylium betaine in moderate yield. Good, regioselectivity and moderate diastereoselectivity were observed.

About this Structure

1Q74 is a Single protein structure of sequence from Mycobacterium tuberculosis with ZN and PE4 as ligands. Full crystallographic information is available from OCA.

Reference

Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton., Aggarwal VK, Grainger RS, Newton GK, Spargo PL, Hobson AD, Adams H, Org Biomol Chem. 2003 Jun 7;1(11):1884-93. PMID:12945769

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