2c2p
From Proteopedia
(New page: 200px<br /> <applet load="2c2p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c2p, resolution 1.75Å" /> '''THE CRYSTAL STRUCTU...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C2P is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]] with ACT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C2P OCA]]. | + | 2C2P is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]] with ACT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C2P OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: uracil-dna glycosylase]] | [[Category: uracil-dna glycosylase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:47:31 2007'' |
Revision as of 06:42, 30 October 2007
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THE CRYSTAL STRUCTURE OF MISMATCH SPECIFIC URACIL-DNA GLYCOSYLASE (MUG) FROM DEINOCOCCUS RADIODURANS
Overview
Deinococcus radiodurans is extremely resistant to the effects of ionizing, radiation. The source of the radiation resistance is not known, but an, expansion of specific protein families related to stress response and, damage control has been observed. DNA repair enzymes are among the, expanded protein families in D. radiodurans, and genes encoding five, different uracil-DNA glycosylases are identified in the genome. Here we, report the three-dimensional structure of the mismatch-specific uracil-DNA, glycosylase (MUG) from D. radiodurans (drMUG) to a resolution of 1.75, angstroms. Structural analyses suggest that drMUG possesses a novel, catalytic residue, Asp-93. Activity measurements show that drMUG has a, modified and broadened substrate specificity compared with Escherichia, coli MUG. ... [(full description)]
About this Structure
2C2P is a [Single protein] structure of sequence from [Deinococcus radiodurans] with ACT as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity., Moe E, Leiros I, Smalas AO, McSweeney S, J Biol Chem. 2006 Jan 6;281(1):569-77. Epub 2005 Oct 12. PMID:16223719
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