1m55
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(New page: 200px<br /><applet load="1m55" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m55, resolution 1.40Å" /> '''Catalytic domain of ...)
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Revision as of 01:39, 25 November 2007
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Catalytic domain of the Adeno Associated Virus type 5 Rep protein
Overview
Adeno-associated virus (AAV), unique among animal viruses in its ability, to integrate into a specific chromosomal location, is a promising vector, for human gene therapy. AAV Replication (Rep) protein is essential for, viral replication and integration, and its amino terminal domain possesses, site-specific DNA binding and endonuclease activities required for, replication initiation and integration. This domain displays a novel, endonuclease fold and demonstrates an unexpected structural relationship, to other viral origin binding proteins such as the papillomavirus E1, protein and the SV40 T antigen. The active site, located at the bottom of, a positively charged cleft, is formed by the spatial convergence of a, divalent metal ion and two conserved sequence motifs that define the, rolling circle replication superfamily.
About this Structure
1M55 is a Single protein structure of sequence from Adeno-associated virus - 5 with ZN and CL as ligands. Full crystallographic information is available from OCA.
Reference
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478
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