1dzl
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(New page: 200px<br /><applet load="1dzl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dzl, resolution 3.50Å" /> '''L1 PROTEIN OF HUMAN ...)
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Revision as of 01:44, 25 November 2007
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L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16
Overview
The papillomavirus major late protein, L1, forms the pentameric assembly, unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro, into capsid-like structures, and truncation of ten N-terminal residues, leads to a homogeneous preparation of 12-pentamer, icosahedral particles., X-ray crystallographic analysis of these particles at 3.5 A resolution, shows that L1 closely resembles VP1 from polyomaviruses. Surface loops, contain the sites of sequence variation among HPV types and the locations, of dominant neutralizing epitopes. The ease with which small virus-like, particles may be obtained from L1 expressed in E. coli makes them, attractive candidate components of a papillomavirus vaccine. Their crystal, structure also provides a starting point for future vaccine design.
About this Structure
1DZL is a Single protein structure of sequence from Human papillomavirus type 13. Full crystallographic information is available from OCA.
Reference
Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140
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