1ydg
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(New page: 200px<br /><applet load="1ydg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ydg, resolution 2.00Å" /> '''Crystal Structure of...)
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Revision as of 01:53, 25 November 2007
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Crystal Structure of Trp repressor binding protein WrbA
Overview
The tryptophan repressor binding protein WrbA binds to the tryptophan, repressor protein TrpR. Although the biological role of WrbA remains, unclear, it has been proposed to function in enhancing the stability of, TrpR-DNA complexes. Sequence database analysis has identified WrbA as a, founding member of a flavodoxin-like family of proteins. Here we present, crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas, aeruginosa and their complexes with flavin mononucleotide. The protomer, structure is similar to that of previously determined long-chain, flavodoxins; however, each contains a conserved inserted region unique to, the WrbA family. Interestingly, each WrbA protein forms a homotetramer, with 222 symmetry, unique among flavodoxin-like proteins, in which each, protomer binds one flavin mononucleotide cofactor molecule.
About this Structure
1YDG is a Single protein structure of sequence from Deinococcus radiodurans with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide., Gorman J, Shapiro L, Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580
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