2ccd
From Proteopedia
(New page: 200px<br /> <applet load="2ccd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ccd, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CCD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CCD OCA]]. | + | 2CCD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CCD OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:48:57 2007'' |
Revision as of 06:44, 30 October 2007
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) AND S315T MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Overview
Inhibition of the enzyme Mycobacterium tuberculosis InhA (enoyl-acyl, carrier protein reductase) due to formation of an isonicotinoyl-NAD adduct, (IN-NAD) from isoniazid (INH) and nicotinamide adenine dinucleotide, cofactor is considered central to the mode of action of INH, a first-line, treatment for tuberculosis infection. INH action against mycobacteria, requires catalase-peroxidase (KatG) function, and IN-NAD adduct formation, is catalyzed in vitro by M. tuberculosis KatG under a variety of, conditions, yet a physiologically relevant approach to the process has not, emerged that allows scrutiny of the mechanism and the origins of INH, resistance in the most prevalent drug-resistant strain bearing, KatG[S315T]. In this report, we describe how hydrogen peroxide, delivered, at very low ... [(full description)]
About this Structure
2CCD is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with HEM as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant., Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS, Biochemistry. 2006 Apr 4;45(13):4131-40. PMID:16566587
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