Human beta two microglobulin
From Proteopedia
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| - | == | + | ==Human beta two microglubulin== |
| - | + | Huamn β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I major histocompatibility complex | |
| - | + | (MHC-I). its function is to ensure proper folding and cell-surface expression of MHC-1. | |
| - | + | The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 um and to its catabolism in the kidney | |
| + | In case of renal dysfunction, b2m concentration increases up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the typical properties of amyloid fibrils, principally in the joints and connective tissue. | ||
| - | Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load | ||
| - | and display another structure. | ||
| - | {{STRUCTURE_1duz | PDB=1duz | SCENE= | + | |
| + | {{STRUCTURE_1duz | PDB=1duz | SCENE= }} | ||
Revision as of 17:58, 12 December 2009
Human beta two microglubulin
Huamn β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I major histocompatibility complex (MHC-I). its function is to ensure proper folding and cell-surface expression of MHC-1. The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 um and to its catabolism in the kidney In case of renal dysfunction, b2m concentration increases up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the typical properties of amyloid fibrils, principally in the joints and connective tissue.
