3jsm

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===K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate===
===K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate===
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{{ABSTRACT_PUBMED_19812032}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:15107837</ref><references group="xtra"/>
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<ref group="xtra">PMID:19812032</ref><ref group="xtra">PMID:15107837</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: RNA-directed DNA polymerase]]
[[Category: RNA-directed DNA polymerase]]
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[[Category: Transferase/dna complex]]
[[Category: Transferase/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:49:04 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 11:32:36 2009''

Revision as of 09:32, 16 December 2009

Image:3jsm.png

Template:STRUCTURE 3jsm

K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate

Template:ABSTRACT PUBMED 19812032

About this Structure

3JSM is a 4 chains structure of sequences from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

Reference

  • Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD Jr, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E. Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. J Biol Chem. 2009 Dec 11;284(50):35092-100. Epub 2009 Oct 7. PMID:19812032 doi:10.1074/jbc.M109.022525
  • Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nat Struct Mol Biol. 2004 May;11(5):469-74. Epub 2004 Apr 25. PMID:15107837 doi:10.1038/nsmb760

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