3kck
From Proteopedia
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===A Novel Chemotype of Kinase Inhibitors=== | ===A Novel Chemotype of Kinase Inhibitors=== | ||
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==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
3KCK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCK OCA]. | 3KCK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCK OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:19945871</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
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[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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Revision as of 09:52, 16 December 2009
Contents |
A Novel Chemotype of Kinase Inhibitors
Template:ABSTRACT PUBMED 19945871
Disease
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]
About this Structure
3KCK is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wang T, Ledeboer MW, Duffy JP, Salituro FG, Pierce AC, Zuccola HJ, Block E, Shlyakter D, Hogan JK, Bennani YL. A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):153-6. Epub 2009 Nov 12. PMID:19945871 doi:10.1016/j.bmcl.2009.11.021
Page seeded by OCA on Wed Dec 16 11:52:24 2009
Categories: Homo sapiens | Non-specific protein-tyrosine kinase | Ledeboer, M W. | Wang, T. | Zuccola, H J. | Atp-binding | Chromosomal rearrangement | Disease mutation | Inhibitor | Jak2 | Janus kinase | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Proto-oncogene | Sh2 domain | Transferase | Tyrosine-protein kinase
